Topic 07 · Radiation & supply · Deep dive

The dose you can't see and the supply chain you never think about

Imaging carries two costs that never appear on the bill. The first is ionizing radiation: a single year of US CT scanning is projected, on a much-debated model, to cause roughly 103,000 future cancers. The second is fragility — half the world's CT contrast came from one factory in Shanghai, the isotopes for nuclear medicine come from a handful of reactors older than most radiologists, and every MRI on Earth depends on a finite, non-renewable gas. Both costs are usually invisible until something goes wrong.

93M
CT examinations performed in the US in 2023, on 62 million patients — up sharply and now above pre-pandemic levels
JAMA Intern Med, 2025
~103k
future cancers projected from one year of those CT scans — a modelled estimate, ~5% of future US cancer diagnoses if practice persists
Smith-Bindman et al., 2025
~50%
of the US iodinated-contrast market that ran through GE's single Shanghai iohexol plant, shut by COVID lockdown in 2022
AJR / Radiology, 2022
40k
US diagnostic scans a day rely on technetium-99m — sourced from a handful of reactors, most over 50 years old
DOE NNSA / ASNC, 2024–25
The dose ladder

Not all scans are equal: a 500-fold spread in radiation

"Imaging radiation" is a category that spans three orders of magnitude. Ultrasound and MRI use none. A chest X-ray is trivial. A multiphase abdominal CT can exceed a nuclear worker's annual limit. Understanding the ladder is the whole basis of "justification and optimisation" — the principle that governs radiation use.

Typical effective dose by exam (mSv)

Adult effective doses; wide real-world variation. Log-scale territory.
Multiphase abdo-pelvis CThighest routine dose
~31
CT coronary angiographymodern scanners much lower
~16
Abdomen-pelvis CT (routine)single phase
~10
Head CTmost common CT
~2
Mammography (screening)2 views/breast
~0.4
Chest X-raythe reference unit
~0.1
Ultrasound / MRIno ionizing radiation
0
Sources: FDA white paper (head 2 mSv, abdomen 8 mSv, CXR 0.02 mSv); Smith-Bindman et al., Arch Intern Med 2009 (median doses, 13-fold within-type variation); Mettler et al. 2008. Values are typical adult effective doses and vary greatly with patient size, protocol and scanner — some sources put CXR at 0.02, others 0.1 mSv. The point is the ladder's shape, not any single rung.

What each dose equals in chest X-rays & background

Two ways to make an abstract number concrete.
Abdomen-pelvis CT~10 mSv
~3 yr
CT coronary angiogram~16 mSv
~5 yr
Head CT~2 mSv
~8 mo
Mammography~0.4 mSv
~7 wk
Chest X-ray~0.1 mSv
~10 d
Sources: RSNA/RadiologyInfo; FDA. Background radiation in the US averages ~3 mSv/yr (about 6.2 mSv including medical). Comparisons express dose as equivalent time of natural background — a communication device, not a claim that the risk profile is identical. Radon is the largest single background source.
26% of exams, 89% of the dose
CT, fluoroscopy and nuclear medicine are only ~26% of US radiation-using imaging procedures but deliver ~89% of the collective medical dose. Since the 1980s, medical imaging's share of per-capita US radiation exposure rose from 15% to ~48% (NCRP).
Same scan, 13× the dose
Dose isn't fixed by exam type. Smith-Bindman's 2009 study found a mean 13-fold variation between highest and lowest dose for the same CT study — up to 22-fold for some. Protocol and scanner settings, not physics, drive most of that spread.
Children carry more risk
Per scan, cancer risk is highest in children — but because adults are scanned so much more, adults accounted for 91% (93,000) of projected cancers in the 2025 model versus 9,700 in children. Head CT drove 53% of the paediatric total.
The 103,000 question

A landmark projection — and the serious dispute around it

In April 2025, JAMA Internal Medicine published the most detailed model yet of CT's population cancer burden. It is an important number and a contested one; this site presents both the estimate and the objection, because the caveat is the story.

Projected lifetime cancers from 2023 US CT scans, by site

Modelled projections from Smith-Bindman et al., JAMA Intern Med 2025.
Total projected cancersfrom 93M scans / 62M patients
~103,000
In adults91% of the total
~93,000
From abdomen & pelvis CTlargest contributor (~40%)
~37,500
In children9% of the total
~9,700
Source: Smith-Bindman R et al., JAMA Intern Med 2025 (corrected June 2025); doses from >120,000 scans scaled to 93M exams via NIH's RadRAT tool. Modelled projection, not observed cancers. Most common projected types: lung then colon. The ACR's rebuttal: this assumes a causal, linear no-threshold relationship extrapolated from BEIR VII coefficients (higher-dose populations), and notes no published study directly links CT scans to cancer. Per-exam risk is ~0.1% lifetime against a ~50% baseline.
Fragility I — one factory

2022: half the world's CT contrast, made in one locked-down building

Radiation is the risk everyone knows. The supply chain is the risk almost no one prices in — until a single point of failure takes it out. The 2022 iodinated-contrast crisis is the cleanest case study in imaging's hidden dependency.

US iodinated-contrast market, pre-2022

Concentration is the vulnerability. Approximate market share.
GE (Omnipaque + Visipaque)much made in Shanghai
>50%
Bracco (Isovue)couldn't take new clients
~45%
Bayer + Guerbet + othersthe entire remainder
<5%
Sources: Vizient via AuntMinnie (2022); systematic review, Eur J Radiol 2023. When GE's Shanghai plant shut, the #2 supplier had no spare capacity and the rest held <5% between them — so there was nowhere for demand to go. Just-in-time inventory (~a week's supply at many sites) turned a factory closure into a clinical emergency within days.

How deep the 2022 shortfall ran

The gap between normal supply and what was available.
Normal supplybaseline
100%
Shanghai plant at peak disruption~⅓ workforce quarantined on-site
~25%
GE's projected near-term supplythrough June 2022
~20%
Achievable use after conservationMelbourne network, modelled floor
~10%
Sources: Radiology (RSNA) 2022; AJNR practice perspective 2022. GE warned of an up-to-80% supply reduction; hospitals postponed cancer-monitoring scans and switched to unenhanced CT, ultrasound and MRI. One large Australian network showed contrast use could be cut to ~10% of baseline through strict conservation — revealing how much routine contrast may have been discretionary.
Fragility II — aging reactors & a finite gas

The isotopes and the coolant: two more single points of failure

Contrast was one dependency. Nuclear medicine rests on a decaying isotope that can't be stockpiled, made in reactors built in the Cold War; and every MRI depends on liquid helium, a non-renewable resource with a history of price shocks.

DependencyThe single point of failureScaleWhy it can't be easily fixed
Technetium-99m~6 aging research reactors (HFR, BR-2, SAFARI-1, LVR-15, Maria)40k US scans/dayMo-99 half-life ~66h — cannot be stockpiled; must be made continuously
Reactor ageFour core producers are >50 years old; unplanned outages rising50+ yrs2024: two reactors down at once (one planned, one not) → global shortage
Iodinated contrastGE's single Shanghai iohexol plant~50% US2022 lockdown; only backup (Cork, Ireland) already at max capacity
MRI heliumConcentrated production (US, Qatar, Russia, Algeria)every MRINon-renewable; supply shocks pushed prices up 50–100% in recent years

Sources: DOE NNSA Mo-99 program & Sept 2025 statement; National Academies, Molybdenum-99 for Medical Imaging (2016); ASNC/SNMMI Oct 2024 alert (HFR pipe deformation, up-to-40% regional Tc-99m shortfall); MRI helium supply reporting (2024–26). Reactor count is approximate — the producer set shifts as reactors retire and new capacity (e.g. SHINE, accelerator-based Mo-99) comes online. Helium figures are industry estimates.

The half-life trap
Technetium-99m has a 6-hour half-life; its parent Mo-99 about 66 hours. You cannot warehouse either — the supply chain must run continuously from reactor to pharmacy to patient in days. A reactor outage becomes a clinical shortage almost immediately.
The HEU-to-HALEU shift
Most Mo-99 was historically made with weapons-usable highly enriched uranium. Under NNSA pressure, all major producers — South Africa's NTP, Netherlands' Curium, Belgium's IRE — have converted to low-enriched targets, a nonproliferation win layered on top of a supply problem.
South Africa in the chain
SAFARI-1 at Pelindaba is one of the world's handful of Mo-99 producers — meaning South Africa is not just a consumer of imaging (Topic 05) but a node in the global isotope supply chain that the US actively helped convert off HEU.

Two invisible costs

Every previous topic on this site has dealt in things you can count on a bill: machines, radiologists, dollars, wait times. This one is about the two costs of imaging that never itemise. The first is radiation, a genuine but easily-overstated risk that the field manages through the twin principles of justification (should this scan happen?) and optimisation (at the lowest dose that answers the question). The second is supply-chain fragility, which is almost never discussed until a factory in Shanghai closes or a Dutch reactor springs a leak — at which point it becomes the only thing radiology departments can talk about. Both costs share a property: they are invisible right up until the moment they are catastrophic.

The dose ladder is the literacy that matters

The single most useful thing a patient or clinician can carry is the shape of the dose ladder. Ultrasound and MRI sit at zero — no ionizing radiation at all. A chest X-ray is a reference unit of about a tenth of a millisievert, roughly ten days of natural background. From there it climbs steeply: a head CT is around twenty chest X-rays, an abdomen-pelvis CT perhaps a hundred, a multiphase study more still. The striking fact buried in the data is that dose is not fixed by exam type — the same CT study varied thirteenfold between the highest- and lowest-dose institutions in Smith-Bindman's work, which means most dose variation is a choice about protocol and equipment, not an inevitability of physics. That is also the good news: it is the part the field can optimise.

The 103,000 number, handled honestly

The 2025 JAMA Internal Medicine projection that a single year of US CT scanning will cause about 103,000 future cancers is the most important — and most contested — statistic in this topic, and it deserves to be presented with its dispute intact rather than as a clean headline. It is a model, not a body count: it scales organ doses from a large sample up to 93 million scans and applies risk coefficients from the BEIR VII framework, which were largely derived from populations exposed to far higher doses than a CT delivers. The American College of Radiology's objection — that no published study has directly linked CT scans to cancer, and that the linear no-threshold extrapolation may overstate low-dose risk — is a legitimate scientific position, not industry defensiveness. The honest reading is that the per-exam risk is small (on the order of 0.1% against a lifetime cancer baseline near 50%), the population-level number is large because the scan count is enormous, and the true value is genuinely uncertain. All three things are true at once.

Concentration is the real supply risk

The through-line of imaging's supply crises is concentration. Half the US contrast market depended on one GE plant; when Shanghai locked down in 2022, the second-largest supplier had no spare capacity and everyone else held under 5% between them, so a factory closure became a national rationing event within days — worsened by just-in-time inventories holding roughly a week's supply. The isotope chain is structurally identical: forty thousand US scans a day depend on technetium-99m eluted from molybdenum-99 that cannot be stockpiled because it decays in hours, produced in a half-dozen reactors mostly older than fifty years, two of which went dark simultaneously in 2024. Helium, cooling every superconducting MRI magnet on the planet, is non-renewable and geographically concentrated enough to have swung 50–100% in price. The uncomfortable lesson the contrast crisis taught — that a large Australian network could run on 10% of its normal contrast when forced to — is double-edged: it shows real resilience is possible, and it hints at how much routine use was never strictly necessary in the first place.

On the data. The 103,000-cancer figure is a modelled projection built on the linear no-threshold hypothesis and BEIR VII risk coefficients; it represents statistically expected cancers, not observed or attributable ones, and is disputed by the ACR and some radiation scientists. Dose values are typical adult effective doses that vary enormously with patient size, protocol and scanner (chest X-ray is quoted anywhere from 0.02 to 0.1 mSv across sources); the ladder's shape is reliable, individual rungs are approximate. Market-share and reactor-count figures are approximate and change as producers enter or exit (SHINE and accelerator-based Mo-99 are scaling up; reactors retire). Helium price and supply figures are industry estimates. The contrast crisis was most acute in the US and Australia; Europe was largely spared, for reasons the literature never fully resolved. Figures span 2008–2026 vintages as labelled.

Sources

  1. Smith-Bindman R et al. — Projected Lifetime Cancer Risks From Current CT Imaging, JAMA Intern Med 2025
  2. NIH Research Matters — Radiation from CT scans and cancer risks (2025 summary; 93M scans, RadRAT)
  3. CT scanning and questions about benefit versus risk — critique of the LNT/BEIR VII assumptions (PMC)
  4. Cancer Health — coverage incl. ACR's "no published studies directly link CT to cancer" response
  5. FDA — white paper on reducing unnecessary radiation exposure (dose table; 26% of exams / 89% of dose)
  6. Smith-Bindman R et al. — Radiation Dose & Lifetime Cancer Risk from common CT, Arch Intern Med 2009 (13-fold variation)
  7. RadiologyInfo (RSNA/ACR) — Radiation Dose from X-Ray and CT Exams (background comparisons)
  8. AJR 2022 — A Health System's Response to the Global Iodinated Contrast Shortage (GE ~50% US market)
  9. Radiology (RSNA) 2022 — Strategies to Manage the Shortage of Iohexol (Shanghai lockdown, ~25% capacity)
  10. Shortage of iodinated contrast media: systematic review, Eur J Radiol 2023 (market shares; US & Australia)
  11. AJNR 2022 — Melbourne network contrast-conservation (use cut to ~10% of baseline)
  12. DOE NNSA (Sept 2025) — domestic Mo-99 production; 2024 dual-reactor shutdown & global shortage
  13. DOE NNSA — Mo-99 program (40,000 US procedures/day; HEU→HALEU conversion: NTP, Curium, IRE)
  14. AuntMinnie (Oct 2024) — Tc-99m shortage from HFR Petten pipe deformation (up to 40% regional shortfall)
  15. National Academies — Molybdenum-99 for Medical Imaging (2016): reactor ages, supply-chain fragility